Cox proportional danger activities were utilized so you’re able to guess RRs and you will 95% CIs

Cox proportional danger activities were utilized so you’re able to guess RRs and you will 95% CIs

RRs (95% CI) off total, ischemic, and you can hemorrhagic shots of the quintiles of mutual diet results getting magnesium, potassium, and you can calcium supplements intakes for the 86,149 ladies in this new NHS I and you may 94,715 ladies in brand new NHS II step one

We updated the meta-analyses from prospective education out-of weight-loss magnesium ( 21), potassium ( 22), and you may calcium ( 23) consumption and you may chance of coronary arrest

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) off total, ischemic, and hemorrhagic shots by the quintiles from shared diet ratings getting magnesium, potassium, and you can calcium supplements consumption inside the 86,149 women in the fresh new NHS I and you will 94,715 women in brand new NHS II step 1

I up-to-date this new meta-analyses out-of possible education off dieting magnesium ( 21), potassium ( 22), and you may calcium supplements ( 23) intakes and you may likelihood of coronary arrest

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

I looked at complete and you can diet consumption of each mineral and risk away from stroke to determine any possible nonlinear association that with limited cubic splines; yet not, zero extreme deviation out-of linearity is seen. Additionally, i browsed the possibility perception amendment by years, blood https://datingranking.net/single-parent-dating/ pressure, otherwise all forms of diabetes toward relation anywhere between overall consumption of all step three vitamins and you will chance of total stroke. No high impact amendment are observed by the these products.

Past meta-analyses incorporated is a result of past analyses in the NHS ( 10); these types of results was basically replaced because of the causes the modern investigation. In addition, the literary works is checked, and you can present possible degree ( 8, 24) was indeed found in this type of up-to-date meta-analyses. Zero anywhere between-studies heterogeneity was noticed for the of one’s step 3 nutrients. New mutual RR regarding complete coronary arrest is 0.87 (95% CI: 0.83, 0.92) getting a hundred-mg/d increase regarding magnesium intake, 0.91 (95% CI: 0.88, 0.94) to have good 1000-mg/d improve of potassium intake, and 0.98 (95% CI: 0.94, step one.02) to have a 3 hundred-mg/d increase off calcium supplements consumption.